荻原克益 准教授 / OGIWARA, Katsueki

生涯研究人生

荻原克益 准教授 /  OGIWARA, Katsueki

研究分野・テーマ・内容

研究分野 生殖生物学
研究テーマ 脊椎動物の排卵機構の解明

研究内容

卵巣は、次世代へと命をつなぐための卵を作ります。卵巣内で十分に成長した卵は、やがて卵巣外へと放出されます。この過程を排卵といいますが、私は、この排卵が起こる仕組みについて研究しています。この仕組みが分かると様々な分野での応用が考えられます。例えば、排卵が起きないために不妊となる方が結構多いのですが、排卵の仕組みが解明されると、このようなケースを改善することができるかもしれません。他にも、家畜の排卵を調節することで、より多くの家畜を容易に生産できるようになることも考えられます。

メッセージ

大きな社会的関心事になっている環境ホルモンやクローン生物、不妊治療、人工繁殖といった問題はいずれも生殖生物学における主要な研究課題です。ところが、これらの問題を含めて、まだまだ未解明な問題が山積み状態なのが現状です。これらの問題にチャレンジしてみたい人、生殖の研究をしてみたい人、一緒に研究をしてみませんか。意欲溢れる皆さんと研究できることを楽しみにしています。

参考文献・論文・著書

  • ・「排卵酵素―排卵研究の歴史とメダカ排卵酵素の同定」
    化学と生物 45巻(9号)655-658. (2007)
  • ・「生殖医学に役立つメダカの排卵研究」
    バイオサイエンスとインダストリー とインダストリー 63巻(12号)767-772. (2005)

nameOGIWARA Katsueki

Research subject

Specialized field

Reproductive Biology

Key words

・Ovary and ovarian follicle
・Ovulation
・Protease
・Endocrine regulation
・Medaka, <i>Oryzias latipes</i>

Research subject

One of the ovarian most significant role is to produce new ova (eggs) to pass a life into next generation. The fully grown ova, which have the ability to be fertilized, are released from the ovary. This process is called ovulation. The process known as follicle rupture has been a subject of intensive investigation over the past century. Previous studies have established that the action of proteolytic enzymes are essential for this process. Despite much effort, the whole picture about ovulation is still not clear. Recently, for the first time in vertebrates, we succeeded in identifying the enzymes that are critically involved in ovulation using medaka fish. We strongly believe this discovery as a huge step forward for our efforts to identify mechanism of ovulation in mammals. We try to identify the mammalian ovulatory enzymes using mouse as an experimental model.

As we have identified the mechanism of ovulation in the medaka, we intend to further expand our search for the regulation of expression of the hydrolytic enzymes and other factors involved in ovulation. To date, there are no available information about gene regulation during ovulation due to the lack of knowledge on ovulatory enzymes. In this study, to reveal the mechanisms for controlling the ovulation, we try to identify the regulatory proteins of the ovulatory enzyme genes. This becomes the first study of this kind in vertebrates and may elucidate a common mechanism to all vertebrates.

message

There are a lot of interesting topics worth studying in reproductive biology. Despite extensive investigations, still there are a lot of unanswered questions in this field. For example, in mammals, the number of oocytes ovulated at a time depends on the species. How it is decided? Many scientists have been studying about this question, but none of them have an answer. Even ovulation, which seems to be much easier to understand, has not been clearly described. Our core purpose is to understand the basic questions and to transform this knowledge to answer the problems in cloned animals, infertility treatments, artificial reproduction and overpopulation. Therefore studying reproductive biology is a strongly felt need in this era.

We welcome dynamic young people with a “can do” attitude who want to be a part of our team to explore new discoveries in this progressive field of science.

references