原著論文

  <2024年>  
 
Sato J., Satoh Y., Yamamoto T., Watanabe T., Matsubara S., Satake H., and Kimura A.P. (2024) PTBP2 binds to a testis-specific long noncoding RNA, Tesra, and activates transcription of the Prss42/Tessp-2 gene. Gene 893: 147907.
PubMed  解説



 
  <2023年>  
 
Iwasaki T., Tokumori M., Matsubara M., Ojima F., Kamigochi K., Aizawa S., Ogoshi M., Kimura A.P., Takeuchi S., and Takahashi S. (2023) A regulatory mechanism of mouse kallikrein 1 gene expression by estrogen. Molecular and Cellular Endocrinology 577: 112044.


Ogiwara K., Fujimori C., and Takahashi T. (2023) The PGE2/Ptger4b pathway regulates ovulation by inducing intracellular actin cytoskeleton rearrangement via the Rho/Rock pathway in the granulosa cells of periovulatory follicles in the teleost medaka. Molecular and Cellular Endocrinology 560: 111816.

 
  <2022年>  
 
Fujimori C., Umatani C., Chimura M., Ijiri S., Bando H., Hyodo S., and Kanda S. (2022) In vitro and in vivo gene transfer in the cloudy catshark (Scyliorhinus torazame), a cartilaginous fish. Development, Growth & Differentiation 64(9): 558-565.
PubMed


Otsuka K., Yang H., Matsubara S., Shiraishi A., Kurihara M., Satake H., and Kimura A.P. (2022) Evidence for a functional role of Start, a long noncoding RNA, in mouse spermatocytes. PLOS ONE 17(8): e0273279. OPEN ACCESS
PubMed  解説


Kabir A.M.R., Munmun T., Hayashi T., Yasuda S., Kimura A.P., Kinoshita M., Murata T., Sada K., and Kakugo A. (2022) Controlling the rigidity of kinesin-propelled microtubules in an in vitro gliding assay using the deep-sea osmolyte trimethylamine N-oxide. ACS Omega 4: 3796-3803.

 

<2021年>



Otsuka K., Matsubara S., Shiraishi A., Takei N., Satoh Y., Terao M., Takada S., Kotani T., Satake H., and Kimura A.P. (2021) A testis-specific long noncoding RNA, Start, is a regulator of steroidogenesis in mouse Leydig cells. Frontiers in Endocrinology 12: 665874. OPEN ACCESS
PubMed  解説


Bandara T.A.M.K., Otsuka K., Matsubara S., Shiraishi A., Satake H., and Kimura A.P. (2021) A dual enhancer-silencer element, DES-K16, in mouse spermatocyte-derived GC-2spd(ts) cells. Biochemical and Biophysical Ressearch Communications 534: 1007-1012.
PubMed  解説





<2020年>



Mayama S., Hamazaki N., Maruyama Y., Matsubara S., and Kimura A.P. (2020) Transcriptional activation of the mouse Scd2 gene by interdependent enhancers and long noncoding RNAs in ovarian granulosa cells. Journal of Reproduction and Development 66: 435-444. OPEN ACCESS
PubMed  解説


Takahashi N., Kimura A.P., Ohmura K., Naito S., Yoshida M., and Ieko M. (2020) Knockdown of long noncoding RNA Dreh facilitates cell surface GLUT4 expression and glucose uptake through the involvement of vimentin in 3T3-L1 adipocytes. Gene 735: 144404.





<2019年>



Takahashi N., Kimura A.P., Otsuka K., Ohmura K., Naito S., Yoshida M., and Ieko M. (2019) Dreh, a long noncoding RNA repressed by metformin, regulates glucose transport in C2C12 skeletal muscle cells. Life Sciences 236: 116906.


Maruyama Y. and Kimura A.P. (2019) A molecular mechanism of mouse placental spongiotrophoblast differentiation regulated by prolyl oligopeptidase. Zygote 27: 49-53.

PubMed  HUSCAP  解説


Satoh Y., Takei N., Kawamura S., Takahashi N., Kotani T., and Kimura A.P. (2019) A novel testis-specific long noncoding RNA, Tesra, activates the Prss42/Tessp-2 gene during mouse spermatogenesis. Biology of Reproduction 100: 833-848. OPEN ACCESS
PubMed  解説




<2018年>



Sasaki R., Kabir A.M.R., Inoue D., Anan S., Kimura A.P., Konagaya A., Sada K., and Kakugo A. (2018) Construction of artificial cilia from microtubules and kinesins through a designed bottom-up approach. Nanoscale 10: 6323-6332. Featuring the cover image


Takei N., Nakamura T., Kawamura S., Takada Y., Satoh Y., Kimura A.P., and Kotani T. (2018) High-sensitivity and high resolution in situ hybridization of coding and long non-coding RNAs in vertebrate ovaries and testes. Biological Procedures Online 20: 6. OPEN ACCESS


Nishimura T., Yamada K., Fujimori C., Kikuchi M., Kawasaki T., Siegfried KR., Sakai N., and Tanaka M. (2018) Germ cells in the teleost fish medaka have an inherent feminizing effect. PLoS Genetics 14(3): 1007259.





<2017年>



Kurihara M., Otsuka K., Matsubara S., Shiraishi A., Satake H., and Kimura A.P. (2017) A testis-specific long non-coding RNA, lncRNA-Tcam1, regulates immune-related genes in mouse male germ cells. Frontiers in Endocrinology 8: 299. OPEN ACCESS
PubMed  HUSCAP  解説


Kimura A.P., Yoneda R., Kurihara M., Mayama S., and Matsubara S. (2017) A long noncoding RNA, lncRNA-mhr2, plays a role in Amhr2 gene activation in mouse ovarian granulosa cells. Endocrinology 158(11): 4105-4121.
PubMed  HUSCAP  解説


Takahashi N., Kimura A.P., Naito S., Yoshida M., Kumano O., Suzuki T., Itaya S., Moriya M., Tsuji M., and Ieko M. (2017) Sarcolipin expression is repressed by endoplasmic reticulum stress in C2C12 myotubes. Journal of Physiology and Biochemistry 73(4): 531-538.


Maruyama Y., Matsubara S., and Kimura A.P. (2017) Mouse prolyl oligopeptidase plays a role in trophoblast stem cell differentiation into trophoblast giant cell and spongiotrophoblast. Placenta 53: 8-15.
PubMed  HUSCAP  解説




<2016年>



Yoneda R.*, Satoh Y.*, Yoshida I., Kawamura S., Kotani T., and Kimura A.P. (2016) A genomic region transcribed into a long noncoding RNA interacts with the Prss42/Tessp-2 promoter in spermatocytes during mouse spermatogenesis, and its flanking sequences can function as enhancers. Molecular Reproduction and Development 83: 541-557. [*equally contributed] Featuring the cover image
PubMed  HUSCAP  解説




<2015年>



Kurihara M. and Kimura A.P. (2015) Characterization of the human TCAM1P pseudogene and its activation by a potential dual promoter–enhancer: Comparison with a protein-coding mouse orthologue. FEBS Letters 589: 540-547.
PubMed  HUSCAP  解説




<2014年>



Kurihara M., Shiraishi A., Satake H., and Kimura A.P. (2014) A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA. Journal of Molecular Biology 426: 3069-3093.
PubMed  HUSCAP  解説


Matsubara S., Kurihara M., and Kimura A.P. (2014) A long non-coding RNA transcribed from conserved non-coding sequences contributes to the mouse prolyl oligopeptidase gene activation. The Journal of Biochemistry 155(4): 243-256.
PubMed  HUSCAP  解説




<2013年>



Yoneda R. and Kimura A.P. (2013) A testis-specific serine protease, Prss41/Tessp-1, is necessary for the progression of meiosis during murine in vitro spermatogenesis. Biochemical and Biophysical Research Communications 441: 120-125.
PubMed  HUSCAP  解説


Matsubara S., Maruyama Y., and Kimura A.P. (2013) A 914-bp promoter is sufficient to reproduce the endogenous prolyl oligopeptidase gene localization in the mouse placenta if not subject to position effect. Gene 524: 114-123.
PubMed  HUSCAP  解説


Yoneda R., Takahashi T., Matsui H., Takano N., Hasebe Y., Ogiwara K., and Kimura A.P. (2013) Three testis-specific serine proteases play different roles in murine spermatogenesis and are involved in germ cell survival during meiosis. Biology of Reproduction 88(5): 118.
PubMed  HUSCAP  解説



  <2012年>  
 
Fujimori C., Ogiwara K., Hagiwara A., and Takahashi T. (2012) New evidence for the involvement of prostaglandin receptor EP4b in ovulation of the medaka, Oryzias latipes. Molecular and Cellular Endocrinology 362: 76–84.

 

<2011年>



Moriyama K., Hanai A., Mekada K., Yoshiki A., Ogiwara K., Kimura A., and Takahashi T. (2011) Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: Identification as an allele of Hyp. Journal of Biomedical Science 18: 60.


Matsubara S., Takahashi T., and Kimura A.P. (2011) Localization and subcellular distribution of prolyl oligopeptidase in the mouse placenta. Journal of Molecular Histology 42: 251-264.
PubMed  HUSCAP  解説


Fujimori C., Ogiwara K., Hagiwara A., Rajapakse S., Kimura A., and Takahashi T. (2011) Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes: Possible involvement in ovulation. Molecular and Cellular Endocrinology 332: 67-77.




<2010年>



Matsubara S., Takahashi T., and Kimura A.P. (2010) Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression. Gene 465: 17-29
PubMed  HUSCAP  解説


Kato Y., Ogiwara K., Fujimori C., Kimura A., and Takahashi T. (2010) Expression and localization of collagen type IV aI chain in the medaka ovary. Cell and Tissue Research 340: 595-605.




<2009年以前・現在の研究に関連する主要なもの>


Takano N., Kimura A., and Takahashi T. (2009) Two distinct localization patterns of testis-specific serine protease 1 (TESSP1) in the seminiferous tubules of the mouse testis. Zoological Science 26: 294-300.
PubMed


Kimura A.P., Sizova D., Handwerger S., Cooke N.E., and Liebhaber S.A. (2007) Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation. Molecular and Cellular Biology 27: 6555-6568.
PubMed


Yoo E.J., Cajiao I., Kim J.-S., Kimura A.P., Zhang A., Cooke N.E., and Liebhaber S.A. (2006) Tissue-specific chromatin modifications at a multigene locus generate asymmetric transcriptional interactions. Molecular and Cellular Biology 26: 5569-5579.
PubMed


Kimura A.P., Liebhaber S.A., and Cooke N.E. (2004) Epigenetic modifications at the human growth hormone locus predict distinct roles for histone acetylation and methylation in placental gene activation. Molecular Endocrinology 18(4): 1018-1032.
PubMed


Kimura A., Matsui H., and Takahashi T. (2002) Expression and localization of prolyl oligopeptidase in mouse testis and its possible involvement in sperm motility. Zoological Science 19: 93-102. 動物学会論文賞・藤井賞受賞
PubMed







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